Differential Bio GmbH
Entry last updated on March 26, 2025

Differential Bio is a Munich-based biotech startup founded by Martin (Software & AI), Dong (Microbiology & HTS), and Christian (Business & Bioinformatics). They are developing a virtual screening platform that uses scale-down experiments and AI-driven models to optimize growth conditions and bioprocesses for microbial growth and production. This drastically increases R&D efficiency and improves fermentation outcomes such as yield, costs, and product quality.

In the long term, they aim to become “The Organism Modeling Company” and thus the standard for in silico bioprocess optimization, from the early R&D phase to large-scale production.

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3

Founders

2024

Founding year

Seed stage

Stage

4

Employees

B2B

Business model

Founder Xiangdong (Dong) Zhao
Dong is a biotech innovator with deep expertise in fungi fermentation, high-throughput screening, and scalable biomanufacturing processes. As the Chief Scientific Officer (CSO) of Differential Bio, she leads the development of sustainable microbial technologies and cutting-edge research. Her work bridges scientific rigor with practical engineering to create transformative solutions in the biotechnology sector.

Martin Patz
Martin is an electrical engineer specializing in neural engineering, AI, and computational technologies for advanced manufacturing. As the Chief Technology Officer (CTO) of Differential Bio, he oversees the integration of state-of-the-art computational tools into biomanufacturing processes. His innovative approach accelerates development cycles and enhances the efficiency of microbial bioproduction.

Christian Spier
Christian is a bioinformatics and business strategy expert with a proven track record in biotech entrepreneurship and venture development. As the Chief Executive Officer (CEO) of Differential Bio, he drives the company's vision, strategy, and partnerships. His leadership combines scientific insight with business acumen to position Differential Bio at the forefront of sustainable biomanufacturing innovation.

Company location

Differential Bio
Olympiastrasse 14
85622 Feldkirchen

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